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Title:

A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency.

Document type:
Journal Article; Journal Article
Author(s):
Stern, Daniel; Weisemann, Jasmin; Le Blanc, Alexander; von Berg, Laura; Mahrhold, Stefan; Piesker, Janett; Laue, Michael; Luppa, Peter B; Dorner, Martin Bernhard; Dorner, Brigitte Gertrud; Rummel, Andreas
Abstract:
The exceptional toxicity of botulinum neurotoxins (BoNTs) is mediated by high avidity binding to complex polysialogangliosides and intraluminal segments of synaptic vesicle proteins embedded in the presynaptic membrane. One peculiarity is an exposed hydrophobic loop in the toxin's cell binding domain HC, which is located between the ganglioside- and protein receptor-binding sites, and that is particularly pronounced in the serotypes BoNT/B, DC, and G sharing synaptotagmin as protein receptor. He...     »
Journal title abbreviation:
PLoS Pathog
Year:
2018
Journal volume:
14
Journal issue:
5
Pages contribution:
e1007048
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.ppat.1007048
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29718991
Print-ISSN:
1553-7366
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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