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Dokumenttyp:
Journal Article 
Autor(en):
Blecha, Jan; Novais, Silvia Magalhaes; Rohlenova, Katerina; Novotna, Eliska; Lettlova, Sandra; Schmitt, Sabine; Zischka, Hans; Neuzil, Jiri; Rohlena, Jakub 
Titel:
Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death. 
Abstract:
Mitochondrial electron transport chain (ETC) targeting shows a great promise in cancer therapy. It is particularly effective in tumors with high ETC activity where ETC-derived reactive oxygen species (ROS) are efficiently induced. Why modern ETC-targeted compounds are tolerated on the organismal level remains unclear. As most somatic cells are in non-proliferative state, the features associated with the ETC in quiescence could account for some of the specificity observed. Here we report that qui...    »
 
Zeitschriftentitel:
Free Radic Biol Med 
Jahr:
2017 
Band / Volume:
112 
Seitenangaben Beitrag:
253-266 
Sprache:
eng 
Print-ISSN:
0891-5849 
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene