Virulence Attenuation through Chemical and Genetic Manipulation of the <em>Staphylococcus aureus</em> ClpXP Protease

Fetzer, Christian

Lehrstuhl für Organische Chemie II (Prof. Sieber)

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Original title:: Virulence Attenuation through Chemical and Genetic Manipulation of the Staphylococcus aureus ClpXP Protease
Translated title:: Verminderung der Virulenz durch Chemische und Genetische Manipulation der Staphylococcus aureus ClpXP Protease
Author:: Fetzer, Christian
Year:: 2017
Document type:: Dissertation
Faculty/School:: Fakultät für Chemie
Advisor:: Sieber, Stephan A. (Prof. Dr.)
Referee:: Sieber, Stephan A. (Prof. Dr.); Feige, Matthias (Prof. Dr.)
Language:: en
Subject group:: CHE Chemie
Keywords:: Staphylococcus aureus; antivirulence; protease; proteomics; inhibitors
Translated keywords:: Staphylococcus aureus; Antivirulenz; Protease; Proteomik; Inhibitoren
TUM classification:: CHE 600d; CHE 800d
Abstract:: The rise of antibiotic resistant bacteria, such as multidrug-resistant Staphylococcus aureus, calls for novel treatment solutions. Targeting of bacterial virulence represents one potential strategy, with the ClpXP protease complex of S. aureus as a crucial regulator. This protease complex was further investigated by chemical and genetic modification. Novel inhibitors of ClpX and ClpXP were discovered and characterized in vitro, as well as in vivo. Genetic modification of clpP revealed new insights into ClpP mediated virulence regulation. «
The rise of antibiotic resistant bacteria, such as multidrug-resistant Staphylococcus aureus, calls for novel treatment solutions. Targeting of bacterial virulence represents one potential strategy, with the ClpXP protease complex of S. aureus as a crucial regulator. This protease complex was further investigated by chemical and genetic modification. Novel inhibitors of ClpX and ClpXP were discovered and characterized in vitro, as well as in vivo. Genetic modification of clpP revealed new insigh... »
Translated abstract:: Das immer häufigere Aufkommen von antibiotikaresistenten Bakterien, wie z.B. Staphylococcus aureus, verlangt nach neuen Strategien zur Lösung des Problems. Die Adressierung der bakteriellen Virulenz stellt eine mögliche Strategie dar. Der ClpXP-Proteasekomplex von S. aureus ist ein wichtiger Regulator der Virulenz und wurde daher, durch chemische und genetische Modifikation, genauer untersucht. Neue Inhibitoren von ClpX und ClpXP wurden entdeckt und sowohl in vitro, als auch in vivo charakterisiert. Zusätzlich ergaben genetische clpP-Modifikationen neue Einsichten in die ClpP vermittelte Virulenzregulation.
WWW:: https://mediatum.ub.tum.de/?id=1399738
Date of submission:: 07.11.2017
Oral examination:: 21.12.2017
File size:: 5810341 bytes
Pages:: 125
Urn (citeable URL):: https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20171221-1399738-1-1
Last change:: 31.12.2018
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