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Dokumenttyp:
journal article 
Autor(en):
Herwerth, M; Kalluri, SR; Srivastava, R; Kleele, T; Kenet, S; Illes, Z; Merkler, D; Bennett, JL; Misgeld, T; Hemmer, B 
Titel:
In Vivo Imaging Reveals Rapid Astrocyte Depletion and Axon Damage in a Model of Neuromyelitis Optica-Related Pathology 
Abstract:
Objective: Neuromyelitis optica (NMO) is an autoimmune disease of the central nervous system, which resembles multiple sclerosis (MS). NMO differs from MS, however, in the distribution and histology of neuroinflammatory lesions and shows a more aggressive clinical course. Moreover, the majority of NMO patients carry immunoglobulin G autoantibodies against aquaporin-4 (AQP4), an astrocytic water channel. Antibodies against AQP4 can damage astrocytes by complement, but NMO histopathology also show...    »
 
Zeitschriftentitel:
Ann Neurol 
Jahr:
2016 
Band / Volume:
79 
Heft / Issue:
Seitenangaben Beitrag:
794-805 
Sprache:
eng 
Volltext / DOI:
Print-ISSN:
0364-5134 
TUM Einrichtung:
Neurologische Klinik und Poliklinik; Institut für Zellbiologie des Nervensystems