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Document type:
Journal Article; Article
Author(s):
Tine, Mbaye; Kuhl, Heiner; Teske, Peter R; Tschöp, Matthias H; Jastroch, Martin
Title:
Diversification and coevolution of the ghrelin/growth hormone secretagogue receptor system in vertebrates.
Abstract:
The gut hormone ghrelin is involved in numerous metabolic functions, such as the stimulation of growth hormone secretion, gastric motility, and food intake. Ghrelin is modified by ghrelin O-acyltransferase (GOAT) or membrane-bound O-acyltransferase domain-containing 4 (MBOAT4) enabling action through the growth hormone secretagogue receptors (GHS-R). During the course of evolution, initially strong ligand/receptor specificities can be disrupted by genomic changes, potentially modifying physiolog...    »
Journal title abbreviation:
Ecol Evol
Year:
2016
Journal volume:
6
Journal issue:
8
Pages contribution:
2516-35
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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