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Document type:
journal article 
Author(s):
Busche, Marc Aurel; Konnerth, Arthur 
Title:
Neuronal hyperactivity--A key defect in Alzheimer's disease? 
Abstract:
Traditionally, the impairment of cognitive functions in Alzheimer's disease (AD) is thought to result from a reduction in neuronal and synaptic activities, and ultimately cell death. Here, we review recent in vivo evidence from mouse models and human patients indicating that, particularly in early stages of AD, neuronal circuits are hyperactive instead of hypoactive. Functional analyses at many levels, from single neurons to neuronal populations to large-scale networks, with a variety of electro...    »
 
Journal title abbreviation:
Bioessays 
Year:
2015 
Journal volume:
37 
Journal issue:
Pages contribution:
624-32 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0265-9247 
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie; Institut für Neurowissenschaften