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Titel:

?III-tubulin: a novel mediator of chemoresistance and metastases in pancreatic cancer.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
McCarroll, Joshua A; Sharbeen, George; Liu, Jie; Youkhana, Janet; Goldstein, David; McCarthy, Nigel; Limbri, Lydia F; Dischl, Dominic; Ceyhan, Güralp O; Erkan, Mert; Johns, Amber L; Biankin, Andrew V; Kavallaris, Maria; Phillips, Phoebe A
Abstract:
Pancreatic cancer is a leading cause of cancer-related deaths in Western societies. This poor prognosis is due to chemotherapeutic drug resistance and metastatic spread. Evidence suggests that microtubule proteins namely, ?-tubulins are dysregulated in tumor cells and are involved in regulating chemosensitivity. However, the role of ?-tubulins in pancreatic cancer are unknown. We measured the expression of different ?-tubulin isotypes in pancreatic adenocarcinoma tissue and pancreatic cancer cel...     »
Zeitschriftentitel:
Oncotarget
Jahr:
2015
Band / Volume:
6
Heft / Issue:
4
Seitenangaben Beitrag:
2235-49
Sprache:
eng
Volltext / DOI:
doi:10.18632/oncotarget.2946
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25544769
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
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