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Document type:
journal article 
Author(s):
Karttunen, Marja J; Czopka, Tim; Goedhart, Marieke; Early, Jason J; Lyons, David A 
Title:
Regeneration of myelin sheaths of normal length and thickness in the zebrafish CNS correlates with growth of axons in caliber. 
Abstract:
Demyelination is observed in numerous diseases of the central nervous system, including multiple sclerosis (MS). However, the endogenous regenerative process of remyelination can replace myelin lost in disease, and in various animal models. Unfortunately, the process of remyelination often fails, particularly with ageing. Even when remyelination occurs, it is characterised by the regeneration of myelin sheaths that are abnormally thin and short. This imperfect remyelination is likely to have imp...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2017 
Journal volume:
12 
Journal issue:
Pages contribution:
e0178058 
Language:
eng 
TUM Institution:
Institut für Zellbiologie des Nervensystems