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Document type:
journal article 
Author(s):
Misgeld, Thomas; Schwarz, Thomas L 
Title:
Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture. 
Abstract:
Neurons have more extended and complex shapes than other cells and consequently face a greater challenge in distributing and maintaining mitochondria throughout their arbors. Neurons can last a lifetime, but proteins turn over rapidly. Mitochondria, therefore, need constant rejuvenation no matter how far they are from the soma. Axonal transport of mitochondria and mitochondrial fission and fusion contribute to this rejuvenation, but local protein synthesis is also likely. Maintenance of a health...    »
 
Journal title abbreviation:
Neuron 
Year:
2017 
Journal volume:
96 
Journal issue:
Pages contribution:
651-666 
Language:
eng 
Print-ISSN:
0896-6273 
TUM Institution:
Institut für Zellbiologie des Nervensystems