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Document type:
journal article 
Author(s):
Kleele, Tatjana; Marinkovi?, Petar; Williams, Philip R; Stern, Sina; Weigand, Emily E; Engerer, Peter; Naumann, Ronald; Hartmann, Jana; Karl, Rosa M; Bradke, Frank; Bishop, Derron; Herms, Jochen; Konnerth, Arthur; Kerschensteiner, Martin; Godinho, Leanne; Misgeld, Thomas 
Title:
An assay to image neuronal microtubule dynamics in mice. 
Abstract:
Microtubule dynamics in neurons play critical roles in physiology, injury and disease and determine microtubule orientation, the cell biological correlate of neurite polarization. Several microtubule binding proteins, including end-binding protein 3 (EB3), specifically bind to the growing plus tip of microtubules. In the past, fluorescently tagged end-binding proteins have revealed microtubule dynamics in vitro and in non-mammalian model organisms. Here, we devise an imaging assay based on trans...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2014 
Journal volume:
Pages contribution:
4827 
Language:
eng 
TUM Institution:
Institut für Zellbiologie des Nervensystems; Institut für Neurowissenschaften