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Title:

Multiple Biological Predictors for Vulnerable Carotid Lesions

Author(s):
Pelisek, Jaroslav; Rudelius, Martina; Zepper, Peter; Poppert, Holger; Reeps, Christian; Schuster, Tibor; Eckstein, Hans-Henning
Abstract:
Background: In this study a multiscore analysis of various biomarkers including matrix metalloproteinases (MMPs), inflammatory factors and other clinical parameters was performed to establish a set of reliable biomarkers for improved detection of plaque instability in patients with advanced carotid stenosis. Methods: Study patients (n = 101) were classified as histologically stable (n = 37) or unstable (n = 64). Serum levels of MMP-1, -2, -3, -7, -8, -9, MMP inhibitors TIMP-1, -2, and inflammato...     »
Keywords:
Carotid artery; Vulnerable plaques; Biomarker; Matrix metalloproteinases; Inflammatory factors
Journal title:
Cerebrovascular Diseases
Year:
2009
Journal volume:
28
Journal issue:
6
Pages contribution:
601--610
Fulltext / DOI:
doi:10.1159/000247605
Publisher:
S. Karger AG
Publisher address:
Basel, Switzerland
Print-ISSN:
1421-9786
E-ISSN:
1421-9786
Notes:
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
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