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- Dokumenttyp:
- Zeitschriftenaufsatz
- Autor(en):
- Zhao, Weining; Lorenz, Nicola; Jung, Kirsten; Sieber, Stephan A.
- Titel:
- Mechanistic analysis of aliphatic (beta)-lactones in Vibrio harveyi reveals a quorum sensing independent mode of action
- Abstract:
- N-Acylhomoserine lactones are autoinducers of quorum sensing (QS) in Gram-negative bacteria. We exploit here the role of structurally related (beta)-lactones in the inhibition of Vibrio harveyi bioluminescence and identify a derivative with nanomolar potency. Surprisingly, QS was not affected and combined proteomic/biochemical studies revealed insights into the cellular mode of action.
- Zeitschriftentitel:
- Chemical communications (Cambridge, England)
- Jahr:
- 2016
- Band / Volume:
- 52
- Heft / Issue:
- 80
- Seitenangaben Beitrag:
- 11971-11974
- Volltext / DOI:
- doi:10.1039/c6cc05807h
- Verlag / Institution:
- Royal Society of Chemistry (RSC)
- Print-ISSN:
- 1359-7345
- E-ISSN:
- 1364-548X
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