Journal Article; Research Support, Non-U.S. Gov't; Review
Bogner, C; Leber, B; Andrews, DW
Apoptosis: embedded in membranes.
Many different signals for cell death converge on outer mitochondrial membrane permeabilization, a process controlled by the Bcl-2 family of proteins. Recent structural and biochemical analyses emphasize that key regulatory interactions between different classes of Bcl-2 family members occur at and in intracellular membranes, and insertion into membranes causes functionally important conformational changes in the proteins.