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Original title:
Targeted and non-targeted studies on Alternaria alternata metabolites
Translated title:
Targeted und non-targeted Studien zu Metaboliten von Alternaria alternata
Author:
Gotthardt, Marina
Year:
2020
Document type:
Dissertation
Faculty/School:
Fakultät Wissenschaftszentrum Weihenstephan
Advisor:
Rychlik, Michael (Prof. Dr.)
Referee:
Rychlik, Michael (Prof. Dr.); Engel, Karl-Heinz (Prof. Dr.)
Language:
en
Subject group:
BIO Biowissenschaften; CHE Chemie
Keywords:
Alternaria alternata, fungi, mycotoxins, AOH, AME, ATX I, ALTP, TEN, TA, alterperylenepoxide A 9-mercaptolactate (APML), LC-MS/MS, stable isotope dilution assay (SIDA), infant food, non-targeted, metabolomics, FT-ICR-MS
Translated keywords:
Alternaria alternata, Schimmelpilze, Mykotoxine, AOH, AME, ATX I, ALTP, TEN, TA, Alterperylenepoxid A 9-Mercaptolactat (APML), LC-MS/MS, Stabilisotopenverdünnungsanalyse (SIVA), Babynahrung, non-targeted, Metabolomics, FT-ICR-MS
TUM classification:
LEB 050d
Abstract:
Fungi of the genus Alternaria are widely occurring plant pathogens infecting a multitude of crops, fruits, and vegetables. In the present thesis, a sensitive LC-MS/MS method for the accurate quantification of the Alternaria mycotoxins alternariol, alternariol monomethyl ether, tentoxin, altertoxin I, alterperylenol, and tenuazonic acid in various foods was developed. Besides, non-targeted metabolomics investigations were conducted by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) to obtain deeper insights into the mycobolome of Alternaria fungi.
Translated abstract:
Schimmelpilze der Gattung Alternaria sind weit verbreitete Pflanzenpathogene, die eine Vielzahl an Getreide-, Obst- und Gemüsesorten befallen. Die vorliegende Arbeit umfasst die Entwicklung einer sensitiven LC-MS/MS-Methode zur exakten Quantifizierung der Alternaria-Mykotoxine Alternariol, Alternariol-Monomethylether, Tentoxin, Altertoxin I, Alterperylenol und Tenuazonsäure in verschiedenen Lebensmitteln. Um tiefergehende Einblicke in das Metabolom von Alternaria-Pilzen zu erhalten, wurden non-...     »
WWW:
https://mediatum.ub.tum.de/?id=1543199
Date of submission:
04.05.2020
Oral examination:
26.10.2020
File size:
15290191 bytes
Pages:
201
Urn (citeable URL):
https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20201026-1543199-1-7
Last change:
03.12.2020
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