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Document type:
Zeitschriftenaufsatz 
Author(s):
Beerenwinkel, N.; Drton, M. 
Title:
A mutagenetic tree hidden Markov model for longitudinal clonal HIV sequence data 
Abstract:
RNA viruses provide prominent examples of measurably evolving populations. In human immunodeficiency virus (HIV) infection, the development of drug resistance is of particular interest because precise predictions of the outcome of this evolutionary process are a prerequisite for the rational design of antiretroviral treatment protocols. We present a mutagenetic tree hidden Markov model for the analysis of longitudinal clonal sequence data. Using HIV mutation data from clinical trials, we estimat...    »
 
Keywords:
EM algorithm; Graphical model; Hidden Markov model; HIV drug resistance; Longitudinal data; Measurably evolving populations; Mutagenetic tree 
Dewey Decimal Classification:
510 Mathematik 
Journal title:
Biostatistics 
Year:
2007 
Journal volume:
Year / month:
2007-01 
Quarter:
1. Quartal 
Month:
Jan 
Journal issue:
Pages contribution:
53-71 
Language:
en 
Publisher:
Oxford University Press (OUP) 
E-ISSN:
1465-46441468-4357 
Date of publication:
28.03.2006 
Format:
Text