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Document type:
Zeitschriftenaufsatz 
Author(s):
McDavid, Andrew; Gottardo, Raphael; Simon, Noah; Drton, Mathias 
Title:
Graphical models for zero-inflated single cell gene expression 
Abstract:
Bulk gene expression experiments relied on aggregations of thousands of cells to measure the average expression in an organism. Advances in microfluidic and droplet sequencing now permit expression profiling in single cells. This study of cell-to-cell variation reveals that individual cells lack detectable expression of transcripts that appear abundant on a population level, giving rise to zero-inflated expression patterns. To infer gene coregulatory networks from such data, we propose a multiva...    »
 
Keywords:
Gene network, single cell gene expression, graphical model, group lasso 
Dewey Decimal Classification:
510 Mathematik 
Journal title:
The Annals of Applied Statistics 
Year:
2019 
Journal volume:
13 
Year / month:
2019-06 
Quarter:
2. Quartal 
Month:
Jun 
Journal issue:
Pages contribution:
848-873 
Language:
en 
Fulltext / DOI:
Publisher:
Institute of Mathematical Statistics 
E-ISSN:
1932-6157 
Date of publication:
17.06.2019