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Document type:
Zeitschriftenaufsatz 
Author(s):
Kimna, Ceren; Lieleg, Oliver 
Title:
Engineering an orchestrated release avalanche from hydrogels using DNA-nanotechnology 
Abstract:
Most medical therapies require repeated, sequential administration of therapeutic agents in well-defined intervals and over extended time windows. Typically, the patient is in charge of applying the individual drug doses, and insufficient patient compliance reduces the efficiency of the treatment. Therefore, the development of a smart delivery mechanism releasing therapeutic agents in a pre-defined, time-controlled fashion would be beneficial for many medical treatments. Here, we present a DNA-m...    »
 
Keywords:
DNA linker, Drug delivery, Nanoparticles, Sequential release 
Journal title:
Journal of Controlled Release 
Year:
2019 
Journal volume:
304 
Pages contribution:
19-28 
Covered by:
Scopus 
Reviewed:
ja 
Language:
en 
Publisher:
Elsevier BV 
E-ISSN:
0168-3659 
Date of publication:
01.06.2019 
TUM Institution:
Fachgebiet für Biomechanik