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Document type:
journal article 
Author(s):
Ovsepian, Saak V; O'Leary, Valerie B; Ntziachristos, Vasilis; Dolly, J Oliver 
Title:
Circumventing Brain Barriers: Nanovehicles for Retroaxonal Therapeutic Delivery. 
Abstract:
In addition to safeguarding the central nervous system (CNS) from the vast majority of pathogens and toxins, transvascular barriers impose immense challenges to the delivery of beneficial cargo. A few toxins and neurotropic viruses capable of penetrating the brain have proved to be potentially valuable for neuron targeting and enhanced transfer of restorative medicine and therapeutic genes. Here we review molecular concepts and implications of the highly neurotropic tetanus toxin (TeTx) and botu...    »
 
Journal title abbreviation:
Trends Mol Med 
Year:
2016 
Journal volume:
22 
Journal issue:
11 
Pages contribution:
983-993 
Language:
eng 
Print-ISSN:
1471-4914 
TUM Institution:
Lehrstuhl für Biologische Bildgebung