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Document type:
journal article 
Author(s):
Zinke, Jenny; Schneider, Fabian T; Harter, Patrick N; Thom, Sonja; Ziegler, Nicole; Toftgård, Rune; Plate, Karl H; Liebner, Stefan 
Title:
?-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma. 
Abstract:
The Wnt/beta-catenin and the Hedgehog (Hh) pathway interact in various cell types while eliciting opposing or synergistic cellular effects. Both pathways are known as exclusive drivers of two distinct molecular subtypes of medulloblastoma (MB). In sonic hedgehog (Shh)-driven MB, activation of Wnt signaling has been shown to suppress tumor growth by either beta-catenin-dependent or -independent inhibition of Shh signaling. However, mechanistic insight in how beta-catenin inhibits the Hh pathway i...    »
 
Journal title abbreviation:
Mol Cancer 
Year:
2015 
Journal volume:
14 
Journal issue:
Pages contribution:
17 
Language:
eng 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie