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Document type:
journal article 
Author(s):
Karampinos, Dimitrios C; Ruschke, Stefan; Gordijenko, Olga; Grande Garcia, Eduardo; Kooijman, Hendrik; Burgkart, Rainer; Rummeny, Ernst J; Bauer, Jan S; Baum, Thomas 
Title:
Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model. 
Abstract:
Bone marrow adiposity has recently gained attention due to its association with bone loss pathophysiology. In this study, ten vertebrae were harvested from fresh human cadavers. Trabecular BMD and microstructure parameters were extracted from MDCT. Bone marrow fat fractions were determined using single-voxel MRS. Failure load (FL) values were assessed by destructive biomechanical testing. Significant correlations (P< 0.05) were observed between MRS-based fat fraction and MDCT-based parameters (up to r = -0.72) and MRS-based fat fraction and FL (r = -0.77). These findings underline the importance of the bone marrow in the pathophysiology and imaging diagnostics of osteoporosis. 
Journal title abbreviation:
J Osteoporos 
Year:
2015 
Journal volume:
2015 
Pages contribution:
152349 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
2090-8059 
TUM Institution:
Institut für Radiologie; Orthopädische und Sportorthopädische Klinik und Poliklinik; Abteilung für Neuroradiologie