User: Guest  Login
Document type:
journal article 
Author(s):
Feuerecker, Benedikt; Seidl, Christof; Pirsig, Sabine; Bruchelt, Gernot; Senekowitsch-Schmidtke, Reingard 
Title:
DCA promotes progression of neuroblastoma tumors in nude mice. 
Abstract:
Even in the presence of oxygen most cancer cells convert glucose to lactate via pyruvate instead of performing oxidative phosphorylation (aerobic glycolysis-Warburg effect). Thus, it has been considered to shift pyruvate - the metabolite of aerobic glycolysis - to acetylCoA by activation of pyruvate dehydrogenase (PDH). AcetylCoA will then be metabolized by oxidative phosphorylation. Therefore, the purpose of this study was to shift tumor cells from aerobic glycolysis to oxidative phosphorylatio...    »
 
Journal title abbreviation:
Am J Cancer Res 
Year:
2015 
Journal volume:
Journal issue:
Pages contribution:
812-20 
Language:
eng 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik; Frauenklinik und Poliklinik