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Document type:
Zeitschriftenaufsatz 
Author(s):
Nowald, Constantin; Penk, Anja; Chiu, Hsin-Yi; Bein, Thomas; Huster, Daniel; Lieleg, Oliver 
Title:
A Selective Mucin/Methylcellulose Hybrid Gel with Tailored Mechanical Properties 
Abstract:
Mucin glycoproteins are key components of native mucus which serves as an initial barrier in the human body against microbial attack. Mucins are able to prevent bacterial adhesion and can trap viruses. However, the weak mechanical properties of mucin solutions have so far prevented their application in a physiological environment. Here, methylcellulose biopolymers are used as mechanical adjuvants to overcome this limitation and generate a thermoresponsive mucin/methylcellulose hybrid system. The...    »
 
Keywords:
biopolymers; drug delivery systems; gelation; hydrogels; selectivity; MESOPOROUS SILICA NANOPARTICLES; PORCINE GASTRIC MUCIN; DRUG-DELIVERY; BACTERIAL ADHESION; LIGHT-SCATTERING; BARRIER; GELATION; HYDROGELS; MEMBRANE; DOXORUBICIN 
Dewey Decimal Classification:
570 Biowissenschaften, Biologie 
Journal title:
Macromol. Biosci. 
Year:
2016 
Journal volume:
16 
Year / month:
2016-04 
Pages contribution:
567-579 
Covered by:
Web of Science 
Reviewed:
ja 
Language:
en 
Fulltext / DOI:
Publisher:
Wiley-Blackwell 
Publisher address:
Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 
Print-ISSN:
1616-5187 
E-ISSN:
1616-5195 
Date of publication:
08.01.2016