Scaling relations between trabecular bone volume fraction and microstructure at different skeletal sites.

Räth, Christoph; Baum, Thomas; Monetti, Roberto; Sidorenko, Irina; Wolf, Petra; Eckstein, Felix; Matsuura, Maiko; Lochmüller, Eva-Maria; Zysset, Philippe K; Rummeny, Ernst J; Link, Thomas M; Bauer, Jan S

doi:10.1016/j.bone.2013.09.004

Document type:: Journal Article; Research Support, Non-U.S. Gov't
Author(s):: Räth, Christoph; Baum, Thomas; Monetti, Roberto; Sidorenko, Irina; Wolf, Petra; Eckstein, Felix; Matsuura, Maiko; Lochmüller, Eva-Maria; Zysset, Philippe K; Rummeny, Ernst J; Link, Thomas M; Bauer, Jan S
Title:: Scaling relations between trabecular bone volume fraction and microstructure at different skeletal sites.
Abstract:: In this study, we investigated the scaling relations between trabecular bone volume fraction (BV/TV) and parameters of the trabecular microstructure at different skeletal sites. Cylindrical bone samples with a diameter of 8mm were harvested from different skeletal sites of 154 human donors in vitro: 87 from the distal radius, 59/69 from the thoracic/lumbar spine, 51 from the femoral neck, and 83 from the greater trochanter. ?CT images were obtained with an isotropic spatial resolution of 26?m. BV/TV and trabecular microstructure parameters (TbN, TbTh, TbSp, scaling indices (< > and ? of ? and ?z), and Minkowski Functionals (Surface, Curvature, Euler)) were computed for each sample. The regression coefficient ? was determined for each skeletal site as the slope of a linear fit in the double-logarithmic representations of the correlations of BV/TV versus the respective microstructure parameter. Statistically significant correlation coefficients ranging from r=0.36 to r=0.97 were observed for BV/TV versus microstructure parameters, except for Curvature and Euler. The regression coefficients ? were 0.19 to 0.23 (TbN), 0.21 to 0.30 (TbTh), -0.28 to -0.24 (TbSp), 0.58 to 0.71 (Surface) and 0.12 to 0.16 (), 0.07 to 0.11 (), -0.44 to -0.30 (?(?)), and -0.39 to -0.14 (?(?z)) at the different skeletal sites. The 95% confidence intervals of ? overlapped for almost all microstructure parameters at the different skeletal sites. The scaling relations were independent of vertebral fracture status and similar for subjects aged 60-69, 70-79, and >79years. In conclusion, the bone volume fraction-microstructure scaling relations showed a rather universal character.
Journal title abbreviation:: Bone
Year:: 2013
Journal volume:: 57
Journal issue:: 2
Pages contribution:: 377-83
Language:: eng
Fulltext / DOI:: doi:10.1016/j.bone.2013.09.004
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/24056252
Print-ISSN:: 8756-3282
TUM Institution:: Fachgebiet Neuroradiologie (Prof. Zimmer); Institut für Medizinische Statistik und Epidemiologie
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