MicroRNAs coordinately regulate protein complexes

Sass, S.; Dietmann, S.; Burk, U. C.; Brabletz, S.; Lutter, D.; Kowarsch, A.; Mayer, K. F. X.; Brabletz, T.; Ruepp, A.; Theis, F. J.; Wang, Y.

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Autor(en):: Sass, S.; Dietmann, S.; Burk, U. C.; Brabletz, S.; Lutter, D.; Kowarsch, A.; Mayer, K. F. X.; Brabletz, T.; Ruepp, A.; Theis, F. J.; Wang, Y.
Titel:: MicroRNAs coordinately regulate protein complexes
Abstract:: BACKGROUND: In animals, microRNAs (miRNAs) regulate the protein synthesis of their target messenger RNAs (mRNAs) by either translational repression or deadenylation. miRNAs are frequently found to be co-expressed in different tissues and cell types, while some form polycistronic clusters on genomes. Interactions between targets of co-expressed miRNAs (including miRNA clusters) have not yet been systematically investigated.RESULTS: Here we integrated information from predicted and experimentally verified miRNA targets to characterize protein complex networks regulated by human miRNAs. We found striking evidence that individual miRNAs or co-expressed miRNAs frequently target several components of protein complexes. We experimentally verified that the miR-141-200c cluster targets different components of the CtBP/ZEB complex, suggesting a potential orchestrated regulation in epithelial to mesenchymal transition. CONCLUSIONS: Our findings indicate a coordinate posttranscriptional regulation of protein complexes by miRNAs. These provide a sound basis for designing experiments to study miRNA function at a systems level. «
BACKGROUND: In animals, microRNAs (miRNAs) regulate the protein synthesis of their target messenger RNAs (mRNAs) by either translational repression or deadenylation. miRNAs are frequently found to be co-expressed in different tissues and cell types, while some form polycistronic clusters on genomes. Interactions between targets of co-expressed miRNAs (including miRNA clusters) have not yet been systematically investigated.RESULTS: Here we integrated information from predicted and experimentally... »
Stichworte:: mir-200 family interaction network mesenchymal transition repressors zeb1 cancer-cells drosophila expression evolution cluster genes
Zeitschriftentitel:: BMC Syst. Biol.
Jahr:: 2011
Band / Volume:: 5
BibTeX

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mediaTUM Gesamtbestand Hochschulbibliographie 2011 Fakultäten Mathematik Lehrstuhl für Angewandte Mathematik in Ökologoe und Medizin (Prof. Lasser R.)

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Computation, Information and Technology Departments Mathematics Lehrstuhl für Mathematische Modellierung biologischer Systeme (Prof. Theis)