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- Original title:
- Matrixmetalloproteinasen und Cathepsine in der Kollagendegradierung im abdominellen Aortenaneurysma
- Translated title:
- Matrixmetalloproteinases and cathepsins in collagen degradation in abdominal aortic aneurysm
- Author:
- Klaus, Veronika
- Year:
- 2018
- Document type:
- Dissertation
- Faculty/School:
- Fakultät für Medizin
- Advisor:
- Pelisek, Jaroslav (Priv.-Doz. Dr.
- Referee:
- Pelisek, Jaroslav (Priv.-Doz. Dr.); Becker, Karl-Friedrich (Prof. Dr.)
- Language:
- de
- Subject group:
- MED Medizin
- TUM classification:
- MED 411d
- Abstract:
- Das Abdominelle Aortenaneurysma ist durch einen Verlust an elastischen Fasern und Kollagenfasern gekennzeichnet. In dieser Arbeit wurden durch Quantifizierung der mRNA und der Proteinmenge relevante Matrixmetalloproteinasen und Cathepsine als kollagenolytische Enzyme identifiziert. Durch Analyse der Korrelationen der Proteasen zu Kollagenen und deren Degradierungsprodukten, scheinen insbesondere MMP-8, -9,-12 und Cathepsin S in die Kollagendegradierung im Aortenaneurysma involviert. Diese Result... »
- Translated abstract:
- Abdominal aortic aneurysms are characterized by a loss of elastic and collagen fibres. In this study relevant collagenolytic matrix metalloproteinases and cathepsins were identified by quantification of mRNA and protein content. By analysing correlations of proteases and collagens and their degradation products, MMP-8 ,-9, -12 and Cathepsin S seem particularly involved in collagen degradation in aortic aneurysms. These results have been published in two papers.
- WWW:
- https://mediatum.ub.tum.de/?id=1459279
- Date of submission:
- 15.11.2018
- Oral examination:
- 20.02.2018
- File size:
- 3113787 bytes
- Pages:
- 72
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20180220-1459279-1-0
- Last change:
- 20.03.2019
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