Curcumin is a powerful modulator of healing processes. However, its hydrophobicity hinders its clinical translation. We present here electrospun curcumin/gelatin blended nanofibrous mats to enhance curcumin bioavailability and show its synergistic signaling for wound repair: (i) mobilization of wound site fibroblasts by activating the Wnt signaling pathway, partly mediated through Dkk-1; (ii) persistent inhibition of the inflammatory response through decreased expression of MCP-1 by fibroblasts.     «

Curcumin is a powerful modulator of healing processes. However, its hydrophobicity hinders its clinical translation. We present here electrospun curcumin/gelatin blended nanofibrous mats to enhance curcumin bioavailability and show its synergistic signaling for wound repair: (i) mobilization of wound site fibroblasts by activating the Wnt signaling pathway, partly mediated through Dkk-1; (ii) persistent inhibition of the inflammatory response through decreased expression of MCP-1 by fibroblasts...     »