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Dokumenttyp:
journal article 
Autor(en):
Fritsche, LG; Freitag-Wolf, S; Bettecken, T; Meitinger, T; Keilhauer, CN; Krawczak, M; Weber, BH 
Titel:
Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene. 
Abstract:
Age-related macular degeneration (AMD) is a frequent, multifactorial disease of the central retina and a major cause of irreversible vision loss in industrialized countries. Apolipoprotein E (APOE) has been consistently associated with AMD, particularly its two functional isoforms E2 (predisposing) and E4 (protective). The biological correlate of this association, however, is still unclear. In this study, we have defined an extended haplotype block encompassing the entire APOE gene locus, includ...    »
 
Zeitschriftentitel:
Hum Mutat 
Jahr:
2009 
Band / Volume:
30 
Heft / Issue:
Seitenangaben Beitrag:
1048-53 
Sprache:
eng 
Print-ISSN:
1059-7794 
TUM Einrichtung:
r Humangenetik