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Dokumenttyp:
journal article 
Autor(en):
Kolz, M; Johnson, T; Sanna, S; Teumer, A; Vitart, V; Perola, M; Mangino, M; Albrecht, E; Wallace, C; Farrall, M; Johansson, A; Nyholt, DR; Aulchenko, Y; Beckmann, JS; Bergmann, S; Bochud, M; Brown, M; Campbell, H; EUROSPAN Consortium; Connell, J; Dominiczak, A; Homuth, G; Lamina, C; McCarthy, MI; ENGAGE Consortium; Meitinger, T; Mooser, V; Munroe, P; Nauck, M; Peden, J; Prokisch, H; Salo, P; Salomaa, V; Samani, NJ; Schlessinger, D; Uda, M; Völker, U; Waeber, G; Waterworth, D; Wang-Sattler, R; Wr...    »
 
Titel:
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. 
Abstract:
Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a meta-analysis of genome-wide association scans from 14 studies totalling 28,141 participants of European descent, resulting in identification of 954 SNPs distributed across nine loci that exceeded the threshold of genome-wide significance, five of which are novel. Overall, the common variants associated with serum...    »
 
Zeitschriftentitel:
PLoS Genet 
Jahr:
2009 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
e1000504 
Sprache:
eng 
Print-ISSN:
1553-7390 
TUM Einrichtung:
r Humangenetik