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Dokumenttyp:
journal article 
Autor(en):
Lindgren, CM; Heid, IM; Randall, JC; Lamina, C; Steinthorsdottir, V; Qi, L; Speliotes, EK; Thorleifsson, G; Willer, CJ; Herrera, BM; Jackson, AU; Lim, N; Scheet, P; Soranzo, N; Amin, N; Aulchenko, YS; Chambers, JC; Drong, A; Luan, J; Lyon, HN; Rivadeneira, F; Sanna, S; Timpson, NJ; Zillikens, MC; Zhao, JH; Almgren, P; Bandinelli, S; Bennett, AJ; Bergman, RN; Bonnycastle, LL; Bumpstead, SJ; Chanock, SJ; Cherkas, L; Chines, P; Coin, L; Cooper, C; Crawford, G; Doering, A; Dominiczak, A; Doney, AS;...    »
 
Titel:
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. 
Abstract:
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two...    »
 
Zeitschriftentitel:
PLoS Genet 
Jahr:
2009 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
e1000508 
Sprache:
eng 
Print-ISSN:
1553-7390 
TUM Einrichtung:
r Humangenetik