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Document type:
journal article 
Author(s):
Schneiderhan, W; Scheler, M; Holzmann, KH; Marx, M; Gschwend, JE; Bucholz, M; Gress, TM; Seufferlein, T; Adler, G; Oswald, F 
Title:
CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models. 
Abstract:
BACKGROUND: CD147 (basigin, EMMPRIN) is a multifunctional, highly conserved glycoprotein enriched in pancreatic ductal adenocarcinomas (PDACs) which is associated with poor prognosis in many malignancies. The role of CD147 in pancreatic cancer, however, remains elusive. METHODS AND RESULTS: Silencing of CD147 by RNA interference (RNAi) reduced the proliferation rate of MiaPaCa2 and Panc1 cells. CD147 is required for the function and expression of the monocarboxylate transporters MCT1 and MCT4 th...    »
 
Journal title abbreviation:
Gut 
Year:
2009 
Journal volume:
58 
Journal issue:
10 
Pages contribution:
1391-8 
Language:
eng 
Print-ISSN:
0017-5749 
TUM Institution:
Urologische Klinik und Poliklinik