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Dokumenttyp:
journal article 
Autor(en):
Cook, AR; Bardswell, SC; Pretheshan, S; Dighe, K; Kanaganayagam, GS; Jabr, RI; Merkle, S; Marber, MS; Engelhardt, S; Avkiran, M 
Titel:
Paradoxical resistance to myocardial ischemia and age-related cardiomyopathy in NHE1 transgenic mice: a role for ER stress? 
Abstract:
Sarcolemmal Na(+)/H(+) exchanger (NHE) activity, which is provided by the NHE isoform 1 (NHE1), has been implicated in ischemia/reperfusion-induced myocardial injury in animal models and humans, on the basis of studies with pharmacological NHE1 inhibitors. We generated a transgenic (TG) mouse model with cardiac-specific over-expression of NHE1 to determine whether this would be sufficient to increase myocardial susceptibility to ischemia/reperfusion-induced injury. TG mouse hearts exhibited incr...    »
 
Zeitschriftentitel:
J Mol Cell Cardiol 
Jahr:
2009 
Band / Volume:
46 
Heft / Issue:
Seitenangaben Beitrag:
225-33 
Sprache:
eng 
Print-ISSN:
0022-2828 
TUM Einrichtung:
r Pharmakologie und Toxikologie