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Dokumenttyp:
journal article 
Autor(en):
Hoffmann, TK; Schirlau, K; Sonkoly, E; Brandau, S; Lang, S; Pivarcsi, A; Balz, V; Müller, A; Homey, B; Boelke, E; Reichert, T; Friebe-Hoffmann, U; Greve, J; Schuler, P; Scheckenbach, K; Schipper, J; Bas, M; Whiteside, TL; Bier, H 
Titel:
A novel mechanism for anti-EGFR antibody action involves chemokine-mediated leukocyte infiltration. 
Abstract:
Overexpression of the epidermal growth factor receptor (EGFR) is a hallmark of squamous cell carcinoma of the head and neck (SCCHN). Monoclonal antibodies (mAbs) against EGFR are currently used for therapy of recurrent or metastatic disease; however, their mode of action is not completely understood. To investigate the immunological effects of anti-EGFR mAb, we generated a three-dimensional spheroid model of EGFR-expressing SCCHN and used this model to study the effect of anti-EGFR mAb on leuko...    »
 
Zeitschriftentitel:
Int J Cancer 
Jahr:
2009 
Band / Volume:
124 
Heft / Issue:
11 
Seitenangaben Beitrag:
2589-96 
Sprache:
eng 
Print-ISSN:
0020-7136 
TUM Einrichtung:
Hals-, Nasen-, Ohrenklinik und Poliklinik