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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Autor(en):
Scheikl, T; Reis, B; Pfeffer, K; Holzmann, B; Beer, S 
Titel:
Reduced notch activity is associated with an impaired marginal zone B cell development and function in Sly1 mutant mice. 
Abstract:
MZ B cells represent a distinct lineage of naive B lymphocytes, apart from FO B cells and peritoneal B1 cells, and mediate humoral immune responses against blood-borne type 2 T-independent antigens. Regulation of MZ B cell development involves the Notch receptor signaling, the intensity of B cell receptor signals, and cell compartmentalization by adhesion and chemokine receptors. Our previous work showed that gene-targeted mice expressing a truncated form of the putative signaling adapter protei...    »
 
Zeitschriftentitel:
Mol Immunol 
Jahr:
2009 
Band / Volume:
46 
Heft / Issue:
Seitenangaben Beitrag:
969-77 
Sprache:
eng 
Print-ISSN:
0161-5890 
TUM Einrichtung:
Chirurgische Klinik und Poliklinik