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- Dokumenttyp:
- Journal Article; Research Support, Non-U.S. Gov't; Article
- Autor(en):
- Ketterer, K; Kong, B; Frank, D; Giese, NA; Bauer, A; Hoheisel, J; Korc, M; Kleeff, J; Michalski, CW; Friess, H
- Titel:
- Neuromedin U is overexpressed in pancreatic cancer and increases invasiveness via the hepatocyte growth factor c-Met pathway.
- Abstract:
- Neuromedin U (NmU) is a bioactive peptide, ubiquitously expressed in the gastrointestinal tract. Here, we analyzed the role of NmU in pancreatic ductal adenocarcinoma (PDAC) pathogenesis. NmU and NmU receptor-2 mRNA were significantly overexpressed in PDAC and in metastatic tissues. NmU and NmU receptor-2 were localized predominantly in cancer cells. NmU serum levels decreased after tumor resection. Although NmU exerted no effects on cancer cell proliferation, it induced c-Met and a trend toward... »
- Zeitschriftentitel:
- Cancer Lett
- Jahr:
- 2009
- Band / Volume:
- 277
- Heft / Issue:
- 1
- Seitenangaben Beitrag:
- 72-81
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1016/j.canlet.2008.11.028
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/19118941
- Print-ISSN:
- 0304-3835
- TUM Einrichtung:
- Chirurgische Klinik und Poliklinik
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