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Document type:
journal article 
Author(s):
Ketterer, K; Kong, B; Frank, D; Giese, NA; Bauer, A; Hoheisel, J; Korc, M; Kleeff, J; Michalski, CW; Friess, H 
Title:
Neuromedin U is overexpressed in pancreatic cancer and increases invasiveness via the hepatocyte growth factor c-Met pathway. 
Abstract:
Neuromedin U (NmU) is a bioactive peptide, ubiquitously expressed in the gastrointestinal tract. Here, we analyzed the role of NmU in pancreatic ductal adenocarcinoma (PDAC) pathogenesis. NmU and NmU receptor-2 mRNA were significantly overexpressed in PDAC and in metastatic tissues. NmU and NmU receptor-2 were localized predominantly in cancer cells. NmU serum levels decreased after tumor resection. Although NmU exerted no effects on cancer cell proliferation, it induced c-Met and a trend toward...    »
 
Journal title abbreviation:
Cancer Lett 
Year:
2009 
Journal volume:
277 
Journal issue:
Pages contribution:
72-81 
Language:
eng 
Print-ISSN:
0304-3835 
TUM Institution:
Chirurgiesche Klinik und Poliklinik