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Dokumenttyp:
journal article 
Autor(en):
Kreutzer, J; Jeske, I; Hofmann, B; Blumcke, I; Fahlbusch, R; Buchfelder, M; Buslei, R 
Titel:
No effect of the PPAR-gamma agonist rosiglitazone on ACTH or cortisol secretion in Nelson's syndrome and Cushing's disease in vitro and in vivo. 
Abstract:
OBJECTIVE: Surgical tumor resection remains the primary treatment strategy in ACTH-secreting pituitary adenomas, i.e. Cushing's disease (CD) and Nelson's syndrome (NS). However, an effective long-term pharmacological regime is not available in patients with persistent ACTH-hypersecretion. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-gamma) is abundantly expressed in most pituitary adenomas. First encouraging data reported that the PPAR-gamma ligand rosiglitazone an...    »
 
Zeitschriftentitel:
Clin Neuropathol 
Jahr:
2009 
Band / Volume:
28 
Heft / Issue:
Seitenangaben Beitrag:
430-9 
Sprache:
eng 
Print-ISSN:
0722-5091 
TUM Einrichtung:
Neurochirurgische Klinik und Poliklinik