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Dokumenttyp:
journal article 
Autor(en):
Hüser, N; Doll, D; Altomonte, J; Werner, M; Kriner, M; Preissel, A; Thorban, S; Matevossian, E 
Titel:
Graft preconditioning with low-dose tacrolimus (FK506) and nitric oxide inhibitor aminoguanidine (AGH) reduces ischemia/reperfusion injury after liver transplantation in the rat. 
Abstract:
Ischemia/reperfusion (I/R) injury is a main cause of primary dysfunction or non-function after liver transplantation (LTx). Recent evidence indicates that an increase in nitric oxide (NO) production after LTx is associated with I/R injury. The aim of this study was to demonstrate that low-dose FK506 in combination with aminoguanidine (AGH), which leads to a reduction of NO levels, has a protective effect by reducing I/R associated injury after LTx. Fortyone DA-(RT1av1) rats served as donors and...    »
 
Zeitschriftentitel:
Arch Pharm Res 
Jahr:
2009 
Band / Volume:
32 
Heft / Issue:
Seitenangaben Beitrag:
215-20 
Sprache:
eng 
Print-ISSN:
0253-6269 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik; r Medizinische Statistik und Epidemiologie