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Document type:
journal article 
Author(s):
Martens, JW; Margossian, AL; Schmitt, M; Foekens, J; Harbeck, N 
Title:
DNA methylation as a biomarker in breast cancer. 
Abstract:
In cancer, epigenetic changes such as covalent addition of methyl groups to the genomic DNA itself are more prominent than genetic changes. Cytosine-phosphate-guanosine (CpG) methylation negatively affects gene transcription of an adjacent gene. It is thought that DNA methylation significantly contributes to all hallmarks of cancer. Next to being a potential therapy target, DNA methylation is an emerging field of biomarkers. Technically, DNA provides a stable and robust analyte that is particula...    »
 
Journal title abbreviation:
Future Oncol 
Year:
2009 
Journal volume:
Journal issue:
Pages contribution:
1245-56 
Language:
eng 
Print-ISSN:
1479-6694 
TUM Institution:
Frauenklinik und Poliklinik