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Dokumenttyp:
journal article 
Autor(en):
Eyerich, S; Eyerich, K; Pennino, D; Carbone, T; Nasorri, F; Pallotta, S; Cianfarani, F; Odorisio, T; Traidl-Hoffmann, C; Behrendt, H; Durham, SR; Schmidt-Weber, CB; Cavani, A 
Titel:
Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. 
Abstract:
Th subsets are defined according to their production of lineage-indicating cytokines and functions. In this study, we have identified a subset of human Th cells that infiltrates the epidermis in individuals with inflammatory skin disorders and is characterized by the secretion of IL-22 and TNF-alpha, but not IFN-gamma, IL-4, or IL-17. In analogy to the Th17 subset, cells with this cytokine profile have been named the Th22 subset. Th22 clones derived from patients with psoriasis were stable in cu...    »
 
Zeitschriftentitel:
J Clin Invest 
Jahr:
2009 
Band / Volume:
119 
Heft / Issue:
12 
Seitenangaben Beitrag:
3573-85 
Sprache:
eng 
Print-ISSN:
0021-9738 
TUM Einrichtung:
r Dermatologie und Allergologie; r Molekulare Allergologie und Umweltforschung