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Document type:
journal article 
Author(s):
Wagner, H 
Title:
The immunogenicity of CpG-antigen conjugates. 
Abstract:
Compared to "live" vaccines the immunogenicity of "split" vaccines is notably poor, because exogeneous antigens (Ag) insufficiently access the MHC class I processing pathway needed for cross-presentation. Here we review our evidence that targeting ligands of endosomally expressed Toll-like Receptors (TLRs), together with exogeneous Ag to endosomes of dendritic cells (DCs) conveys immunogenicity to Ag similar in magnitude as "live" vaccines that produce Ag. We explored the consequences of enforce...    »
 
Journal title abbreviation:
Adv Drug Deliv Rev 
Year:
2009 
Journal volume:
61 
Journal issue:
Pages contribution:
243-7 
Language:
eng 
Print-ISSN:
0169-409X 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene