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Dokumenttyp:
journal article 
Autor(en):
Helming, L; Winter, J; Gordon, S 
Titel:
The scavenger receptor CD36 plays a role in cytokine-induced macrophage fusion. 
Abstract:
Multinucleated giant cells, characteristic of granulomatous infections, originate from the fusion of macrophages. Using an antibody screening strategy we found that the scavenger receptor CD36 participates in macrophage fusion induced by the cytokines IL-4 and GM-CSF. Our results demonstrate that exposure of phosphatidylserine on the cell surface and lipid recognition by CD36 are required for cytokine-induced fusion of macrophages. We also show that CD36 acts in a heterotypic manner during giant...    »
 
Zeitschriftentitel:
J Cell Sci 
Jahr:
2009 
Band / Volume:
122 
Heft / Issue:
Pt 4 
Seitenangaben Beitrag:
453-9 
Sprache:
eng 
Print-ISSN:
0021-9533 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene