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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't 
Autor(en):
Brenk, M; Scheler, M; Koch, S; Neumann, J; Takikawa, O; Häcker, G; Bieber, T; von Bubnoff, D 
Titel:
Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4+CD25+ Foxp3+ T regulatory cells. 
Abstract:
Tryptophan catabolism through IDO activity can cause nonresponsiveness and tolerance acting on T cells. Given the crucial importance of dendritic cells (DCs) in the initiation of a T cell response, surprisingly little is known about the impact of IDO activity and tryptophan deprivation on DCs themselves. In the present study, we show that human DCs differentiated under low-tryptophan conditions acquire strong tolerogenic capacity. This effect is associated with a markedly decreased Ag uptake as...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2009 
Band / Volume:
183 
Heft / Issue:
Seitenangaben Beitrag:
145-54 
Sprache:
eng 
Volltext / DOI:
Print-ISSN:
0022-1767 
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene