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Dokumenttyp:
journal article 
Autor(en):
Ablasser, A; Poeck, H; Anz, D; Berger, M; Schlee, M; Kim, S; Bourquin, C; Goutagny, N; Jiang, Z; Fitzgerald, KA; Rothenfusser, S; Endres, S; Hartmann, G; Hornung, V 
Titel:
Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes. 
Abstract:
Detection of non-self RNA by TLRs within endosomes and by retinoic acid-inducible gene I (RIG-I)-like helicases in the cytosol is central to mammalian antiviral immunity. In this study, we used pathway-specific agonists and targeted delivery to address RNA immunorecognition in primary human immune cells. Within PBMC, plasmacytoid dendritic cells (pDC) and monocytes were found to be responsible for IFN-alpha production upon immunorecognition of RNA. The mechanisms of RNA recognition in pDC and mo...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2009 
Band / Volume:
182 
Heft / Issue:
11 
Seitenangaben Beitrag:
6824-33 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik