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Dokumenttyp:
journal article 
Autor(en):
Neuhierl, B; Feederle, R; Adhikary, D; Hub, B; Geletneky, K; Mautner, J; Delecluse, HJ 
Titel:
Primary B-cell infection with a deltaBALF4 Epstein-Barr virus comes to a halt in the endosomal compartment yet still elicits a potent CD4-positive cytotoxic T-cell response. 
Abstract:
Epstein-Barr virus (EBV) infection is mediated by several viral envelope glycoproteins. We have assessed gp110's functions during the virus life cycle using a mutant that lacks BALF4 (DeltaBALF4). Exposure of various cell lines and primary cell samples of epithelial or lymphoid lineages to the DeltaBALF4 mutant failed to establish stable infections. The DeltaBALF4 virus, however, did not differ from wild-type EBV in its ability to bind and become internalized into primary B cells, in which it el...    »
 
Zeitschriftentitel:
J Virol 
Jahr:
2009 
Band / Volume:
83 
Heft / Issue:
Seitenangaben Beitrag:
4616-23 
Sprache:
eng 
Print-ISSN:
0022-538X 
TUM Einrichtung:
Kinderklinik und Poliklinik