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Dokumenttyp:
journal article 
Autor(en):
Beier, KC; Humberdros, S; Witt, H; Illi, S; Rüschendorf, F; Nickel, R; Lee, YA; Lau, S; Wahn, U; Hamelmann, E 
Titel:
ICOS-gene variants are not associated with atopic disease susceptibility in European children. 
Abstract:
The inducible co-stimulatory molecule, ICOS, is an important regulator of T cell differentiation and effector function. Previously, it was reported that two variants in the ICOS promotor region, g.1-1413G>A and g.1-693G>A, were associated with sensitization to airborne allergens, elevated serum IgE levels and Th2 cytokine production in a Hutterite population. The aim of this study was to evaluate these two and four other selected ICOS variants for association with atopic phenotypes in two large...    »
 
Zeitschriftentitel:
Pediatr Allergy Immunol 
Jahr:
2009 
Band / Volume:
20 
Heft / Issue:
Seitenangaben Beitrag:
242-5 
Sprache:
eng 
Print-ISSN:
0905-6157 
TUM Einrichtung:
Kinderklinik und Poliklinik