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Document type:
journal article 
Author(s):
Halangk, J; Berg, T; Neumann, K; Sarrazin, C; Hinrichsen, H; Fitz, C; Puhl, G; Mueller, T; Neuhaus, P; Wiedenmann, B; Witt, H 
Title:
Evaluation of angiotensinogen c.1-44G>A and p.M268T variants as risk factors for fibrosis progression in chronic hepatitis C and liver diseases of various etiologies. 
Abstract:
BACKGROUND: Hepatic stellate cells express all components of the renin-angiotensinogen (AGT) system and secrete active angiotensin II. Animal studies provided evidence that angiotensin II stimulates the accumulation of extracellular matrix by enhancing transforming growth factor beta1 production. A functional genetic alteration in the human AGT promoter (c.1-44G>A) has been linked to accelerated progression of fibrosis in hepatitis C virus infection. METHODS: We enrolled 2154 patients with chron...    »
 
Journal title abbreviation:
Genet Test Mol Biomarkers 
Year:
2009 
Journal volume:
13 
Journal issue:
Pages contribution:
407-14 
Language:
eng 
Print-ISSN:
1945-0265 
TUM Institution:
Kinderklinik und Poliklinik