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Dokumenttyp:
journal article 
Autor(en):
Mollweide, A; Staege, MS; Hoeschen, C; Hideo, Y; Burdach, S; Richter, GH 
Titel:
Only therapeutic ICOS:ICOSL blockade alleviates acute graft versus host disease. 
Abstract:
Inducible co-stimulator (ICOS) interaction with its ligand (ICOSL) is involved in several T cell effector functions. While blockade of ICOS:ICOSL interaction in chronic graft versus host disease (GVHD) seems beneficial, results for acute GVHD remain controversial. To further elucidate its role in acute GVHD, C57BL/6 mice were reconstituted with allogeneic spleen cells in the absence or presence of ICOSL-blocking mAb. Mice reconstituted with allogeneic spleen cells experienced severe GVHD and die...    »
 
Zeitschriftentitel:
Klin Padiatr 
Jahr:
2009 
Band / Volume:
221 
Heft / Issue:
Seitenangaben Beitrag:
344-50 
Sprache:
eng 
Print-ISSN:
0300-8630 
TUM Einrichtung:
Kinderklinik und Poliklinik