User: Guest  Login
Document type:
journal article 
Author(s):
Bollrath, J; Phesse, TJ; von Burstin, VA; Putoczki, T; Bennecke, M; Bateman, T; Nebelsiek, T; Lundgren-May, T; Canli, O; Schwitalla, S; Matthews, V; Schmid, RM; Kirchner, T; Arkan, MC; Ernst, M; Greten, FR 
Title:
gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. 
Abstract:
Although gastrointestinal cancers are frequently associated with chronic inflammation, the underlying molecular links have not been comprehensively deciphered. Using loss- and gain-of-function mice in a colitis-associated cancer model, we establish here a link comprising the gp130/Stat3 transcription factor signaling axis. Mutagen-induced tumor growth and multiplicity are reduced following intestinal epithelial cell (IEC)-specific Stat3 ablation, while its hyperactivation promotes tumor incidenc...    »
 
Journal title abbreviation:
Cancer Cell 
Year:
2009 
Journal volume:
15 
Journal issue:
Pages contribution:
91-102 
Language:
eng 
Print-ISSN:
1535-6108 
TUM Institution:
II. Medizinische Klinik und Poliklinik