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Document type:
journal article 
Author(s):
Ludwig, L; Oswald, F; Hoang-Vu, C; Dralle, H; Hildt, E; Schmid, RM; Karges, W 
Title:
Expression of the Grb2-related RET adapter protein Grap-2 in human medullary thyroid carcinoma. 
Abstract:
Inappropriate signaling of the RET receptor tyrosine kinase causes different forms of human thyroid malignancy. We have previously identified the adaptor Grap-2 as RET binding protein. To verify involvement of Grap-2 in RET oncogenic signaling we performed sequence and expression analysis of Grap-2 in 15 human MTC samples. All tumors displayed marked Grap-2 mRNA and protein expression without a linear correlation. Beyond one conservative base pair substitution we detected no further alteration i...    »
 
Journal title abbreviation:
Cancer Lett 
Year:
2009 
Journal volume:
275 
Journal issue:
Pages contribution:
194-7 
Language:
eng 
Print-ISSN:
0304-3835 
TUM Institution:
II. Medizinische Klinik und Poliklinik