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Document type:
journal article 
Author(s):
Vlaskou, D; Mykhaylyk, O; Krotz, F; Hellwig, N; Renner, R; Schillinger, U; Gleich, B; Heidsieck, A; Schmitz, G; Hensel, K; Plank, C 
Title:
Magnetic and Acoustically Active Lipospheres for Magnetically Targeted Nucleic Acid Delivery 
Abstract:
With the aim of obtaining a carrier for combined magnetic-field-and ultrasound-targeted nucleic acid delivery, acoustically active lipospheres are prepared that comprise magnetic nanoparticles and plasmid DNA or synthetic siRNA. The lipospheres, with average diameters of 5 mu m and smaller, are obtained upon shaking a mixture of soybean oil, a cationic lipid, magnetic nanoparticles, a nucleic acid, and aqueous buffer in a perfluoropropane atmosphere in a sealed vial. These lipospheres create con...    »
 
Journal title abbreviation:
Adv Funct Mater 
Year:
2010 
Journal volume:
20 
Journal issue:
22 
Pages contribution:
3881-3894 
Language:
eng 
Print-ISSN:
1616-301X 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung