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Document type:
journal article 
Author(s):
Hönig, D; DeRouchey, J; Jungmann, R; Koch, C; Plank, C; Rädler, JO 
Title:
Biophysical characterization of copolymer-protected gene vectors. 
Abstract:
A copolymer-protected gene vector (COPROG) is a three-component gene delivery system consisting of a preformed DNA and branched polyethylenimine (bPEI) complex subsequently modified by the addition of a copolymer (P6YE5C) incorporating both poly(ethylene glycol) (PEG) and anionic peptides. Using fluorescence correlation spectroscopy (FCS) and atomic force microscopy (AFM), we characterized and compared the self-assembly of bPEI/DNA particles and COPROG complexes. In low salt buffer, both bPEI/DN...    »
 
Journal title abbreviation:
Biomacromolecules 
Year:
2010 
Journal volume:
11 
Journal issue:
Pages contribution:
1802-9 
Language:
eng 
Print-ISSN:
1525-7797 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung